Esophageal high resolution manometry in neurologically impaired children and gastro-oesophageal reflux disease

Abstract

s / Digestive and Liver Disease 46 (2014) e71–e84 e81 genotyped by DMET technology, with colon cancer and GI toxicity induced by irinotecan. Conclusions: In conclusion, according to our preliminary findings, the heterozygous genotype G/A in the (rs55802895) NR1I3 gene seems to be associated with the altered gastrointestinal function in FD. http://dx.doi.org/10.1016/j.dld.2014.07.043 EFFECT OF MAGNESIUM ALGINATE PLUS SIMETHICONE ON GASTROESOPHAGEAL REFLUX IN INFANTS: A RANDOMIZED, OPEN TRIAL Dario Ummarino ∗, Erasmo Miele, Massimo Martinelli, Elena Scarpato, Felice Crocetto, Elisa Sciorio, Annamaria Staiano Dipartimento di Scienze Mediche Traslazionale, Sezione Pediatria, Universita degli Studi di Napoli Federico II, Napoli, Italy Objectives: Gastroesophageal reflux (GER) is a frequent condition in infants that can cause distressing symptoms. The aim of our study is to evaluate the efficacy of Mg-alginate plus simethicone (Gastrotuss Baby®), compared to rice-starch-thickened formula or to reassurance alone, in the treatment of GER in infants. Methods: This randomized, controlled trial was conducted in full-term infants affected by symptoms suggestive of GER, evaluated through a validated questionnaire (I-GERQ-R). The patients were randomized in3groups according to treatment [GroupA:Mgalginate plus simethicone (Gastrotuss Baby®); Group B: Thickened formula; Group C: reassurance with lifestyle changes]. The evaluation of the symptom scores was performed after one month (T1) and two months (T2). Results: Sixty-four (85.3%) out of 75 enrolled infants (median age: 5 months; range: 1–10), concluded the study. After one month of treatment (T1), infants treated with Mg-alginate plus simethicone (Gastrotuss Baby®) showed a statistically significant improvement of symptoms compared with the thickened formula and reassurance (p 24 months (p 0.0001) and was similar in the two decades. Conclusions: Our study showed that IFALD occurs early in the natural history of SBS. This suggests that it may depend on the underlying disease and on its early complications (repeated surgery, sepsis) rather than the factors related to the PN duration. This is also supported by the evidence of the unchanged prevalence of IFALD over the years in spite of advances in the PNmanagement. http://dx.doi.org/10.1016/j.dld.2014.07.045 WAIST TO HEIGHT RATIO: A SIMPLE TOOL TO RECOGNISE CHILDREN AT INCREASED RISK FOR METABOLIC SYNDROME Angelo Campanozzi1,∗, Irene Rutigliano1, Donatella De Giovanni1, Michela Foglia1, Mariangela Guglielmi1, Gianpaolo De Filippo2, Luciana Romaniello1, Valentina De Maio1, Michele Conoscitore1, Massimo Pettoello-Mantovani1 1 Clinica Pediatrica, Universita’ di Foggia, Foggia, Italy 2 Pediatria, Ospedale Bicetre, Parigi, France Objective: Metabolic Syndrome (MS) is the most important comorbidity obesity-related, also in children. Visceral adiposity is part of MS cluster, so that measurement of Waist Circumference (WC) is an essential step for screening MS in adulthood and childhood. Up today, valid cut-off percentiles for WC are not available for the whole pediatric population, arising difficulties to diagnose the MS. Aim of the study: To individuate a simple clinical diagnostic tool for screening obese children at risk for MS. Methods:Weenrolled in the study803 subjects (395girls,mean age 9.43±2.5 yrs) whose mean BMI z-score was 2.2±0.53. The