Abstract
To summarize the endoscopic screening findings in high-risk population of esophageal and gastric carcinoma and analyze influential factors related to screening. In seven selected cities and counties with high incidences of esophageal carcinoma, people at age of 40-69 were set as the target population. Those with gastroscopy contradictions were excluded, and all who were voluntary and willing to comply with the medical requirements were subjected to endoscopic screening and histological examination for esophageal, gastric cardia and gastric carcinoma in accordance with national technical manual for early detection and treatment of cancer. In three years, 36,154 people were screened, and 16,847 (46.60%) cases were found to have precancerous lesions. A total of 875 cases were found to have cancers (2.42%), and among them 739 cases had early stage with an early diagnosis rate is 84.5%. Some 715 patients underwent prompt treatment and the success rate was 81.8%. In a high-risk population of esophageal and gastric carcinoma, it is feasible to implement early detection and treatment by endoscopic screening. Screening can identify potential invasive carcinoma, early stage carcinoma and precancerous lesions, improving efficacy through early detection and treatment. The exploratory analysis of related influential factors will help broad implementation of early detection and treatment for esophageal and gastric carcinoma.
Highlights
With the approach into the twenty-first century, esophageal carcinoma and gastric carcinoma remain the most common malignant tumors in China, even in the whole world (National institute of cancer prevention, 2008; Ministry of health, bureau of disease control and prevention, 2011; Ferlay et al, 2010; Zhao et al, 2012; Henan research division of cancer prevention, 2012)
Those with gastroscopy contradictions were excluded, and all who were voluntary and willing to comply with the medical requirements were subjected to endoscopic screening and histological examination for esophageal, gastric cardia and gastric carcinoma in accordance with national technical manual for early detection and treatment of cancer
According to 2010 annual cancer registration report by international agency for research on cancer (IARC, WHO), there are 12, 700,000 new cases of cancer and 7,600,000 people died of cancer
Summary
There are 481,000 new cases of esophageal carcinoma and 460,000 patients died, and eighty-three percent occurs in the developing countries. In China, there are 258,000 new cases and 210,000 deaths, which account for over fifty percent of total morbidity and mortality in the whole world. There are 9,880,000 new cases of gastric carcinoma and 736,000 deaths, and seventy percent occurs in developing country. In China, there are 463,000 new cases of gastric carcinoma and 352,000 deaths, which accounts for forty-eight percent of total cases (Ferlay et al, 2010). From 2009 to 2011, seven counties and cities in Henan province participated in the national early detection and treatment project for esophageal and gastric carcinoma, and completed endoscopic screening and histological examination in 36, 154 cases (at age of 40-69). We reported the endoscopic and histological findings in high-risk population of esophageal and gastric carcinoma and analyzed the related factors which may affect the screening results
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