Abstract
BackgroundLeukemoid reaction (LR) is defined as a reactive leucocytosis with WBC counts exceeding 50,000/mm3, and a significant increase in early neutrophil precursors. LR may be a paraneoplastic manifestation of various malignant tumors. Tumor-related LR is a kind of neoplastic syndrome, unrelated to an infection or other diseases.Case presentationA 74-year-old male visited a local doctor with a 20-day history of progressive dysphagia. The complete blood count revealed leucocytosis. Bone marrow aspirates and a biopsy confirmed LR and excluded chronic myelogenous leukemia. Following radical esophagectomy for an adenocarcinoma the WBC counts successively decreased to 10,450/mm3 and 8670/mm3 within 1 week and 1 month, respectively.ConclusionWe report a rare case of esophageal adenocarcinoma complicated with excessive leucocytosis caused by paraneoplastic LR; we also present a review of literature and an investigation of the clinical features. To our knowledge, this is the first report of LR associated with esophageal adenocarcinoma.
Highlights
ConclusionWe report a rare case of esophageal adenocarcinoma complicated with excessive leucocytosis caused by paraneoplastic Leukemoid reaction (LR); we present a review of literature and an investigation of the clinical features
Leukemoid reaction (LR) is defined as a reactive leucocytosis with white blood cell (WBC) counts exceeding 50,000/ mm3, and a significant increase in early neutrophil precursors
We report a rare case of esophageal adenocarcinoma complicated with excessive leucocytosis caused by paraneoplastic LR; we present a review of literature and an investigation of the clinical features
Summary
We report a rare case of esophageal adenocarcinoma complicated with excessive leucocytosis caused by paraneoplastic LR; we present a review of literature and an investigation of the clinical features.
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