Abstract
Based on Staudinger ligation, a novel ESIPT-based fluorescent probe 2-[2′-(ortho-diphenylphosphinophenyl) carboxyphenyl]benzothiazole (CBT) was developed for detection of organic azides with the detection limit of 227nM. The probe has shown selective and sensitive response to organic azides over other non-azido analytes. The probe was used as a fluorescence turn-on chemosensor for phenyl azide in living hepatoma SMMC-7721 cells, indicating its potential application for detection of organic azide derivatives in biological systems. Moreover, the probe provides a very convenient method to qualitatively monitor the formation of organic azides by TLC staining experiments.
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