ESHRE PGT Consortium data collection XVI-XVIII: cycles from 2013 to 2015.

Abstract

STUDY QUESTIONWhat are the trends and developments in preimplantation genetic testing (PGT) in 2013–2015 as compared to previous years?SUMMARY ANSWERThe main trends observed in the retrospective data collections 2013–2015, representing valuable data on PGT activity in (mainly) Europe, are the increased application of trophectoderm biopsy at the cost of cleavage stage biopsy and the continuing expansion of comprehensive testing technology in PGT for chromosomal structural rearrangements and for aneuploidies (PGT-SR and PGT-A).WHAT IS KNOWN ALREADYSince it was established in 1997, the ESHRE PGT Consortium has been collecting data from international PGT centres. To date, 15 data sets and an overview of the first 10 years of data collections have been published.STUDY DESIGN, SIZE, DURATIONCollection of (mainly) European data by the PGT Consortium for ESHRE. The data for PGT cycles performed between 1 January 2013 and 31 December 2015 were provided by participating centres on a voluntary basis. For the collection of cycle, pregnancy and baby data, separate, pre-designed MS Excel tables were used.PARTICIPANTS/MATERIALS, SETTING, METHODSData were submitted by 59, 60 and 59 centres respectively for 2013, 2014 and 2015 (full PGT Consortium members). Records with incomplete or inconsistent data were excluded from the calculations. Corrections, calculations, figures and tables were made by expert co-authors.MAIN RESULTS AND THE ROLE OF CHANCEFor data collection XVI/XVII/XVIII, 59/60/59 centres reported data on 8164/9769/11 120 cycles with oocyte retrieval: 5020/6278/7155 cycles for PGT-A, 2026/2243/2661 cycles for PGT for monogenic/single gene defects, 1039/1189/1231 cycles for PGT-SR and 79/59/73 cycles for sexing for X-linked diseases. From 2013 until 2015, the uptake of biopsy at the blastocyst stage was mainly observed in cycles for PGT-A (from 23% to 36%) and PGT-SR (from 22% to 36%), alongside the increased application of comprehensive testing technology (from 66% to 75% in PGT-A and from 36% to 58% in PGT-SR).LIMITATIONS, REASONS FOR CAUTIONThe findings apply to the 59/60/59 participating centres and may not represent worldwide trends in PGT. Data were collected retrospectively and no details of the follow-up on PGT pregnancies and babies born were provided.WIDER IMPLICATIONS OF THE FINDINGSBeing the largest data collection on PGT worldwide, detailed information about ongoing developments in the field is provided.STUDY FUNDING/COMPETING INTEREST(S)The study has no external funding and all costs are covered by ESHRE. There are no competing interests declared.TRIAL REGISTRATION NUMBERN/A.