Abstract
A substantial majority of patients with Hodgkin's lymphoma are now cured, but at the price of complications such as secondary cancers. Two avenues are currently being pursued to improve these results: lowering of the amount of radiation therapy in localised disease, and improvement of chemotherapy regimens in patients with disseminated disease. Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trialTreatment with six cycles of BEACOPPescalated followed by PET-guided radiotherapy was more effective in terms of freedom from treatment failure and less toxic than eight cycles of the same chemotherapy regimen. Thus, six cycles of BEACOPPescalated should be the treatment of choice for advanced stage Hodgkin's lymphoma. PET done after chemotherapy can guide the need for additional radiotherapy in this setting. Full-Text PDF
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