Abstract
In England in 2015, Shigella sonnei isolates from men who have sex with men produced extended-spectrum β-lactamases and exhibited macrolide resistance. Whole-genome sequencing showed a close relationship among the isolates, which harbored a plasmid that was previously identified in a shigellosis outbreak among this population but has acquired a mobile element.
Highlights
We describe an investigation of a cluster of multidrug-resistant S. sonnei infections among men who have sex with men (MSM) in England during 2015
The Study In November 2015, Public Health England (PHE) identified a cluster of S. sonnei isolates by analyzing wholegenome sequencing data from specimens collected during September and October from 4 adult men residing in London and having no known travel history
We describe a phylogenetic cluster of ESBL-producing S. sonnei infections in MSM in England that raises concerns about the ability to manage the spread of resistant Shigella infection in this population
Summary
In England in 2009, Shigella flexneri 3a infections dramatically increased among men who have sex with men (MSM) and were thought to be associated with sexual transmission [1]. We describe an investigation of a cluster of multidrug-resistant S. sonnei infections among MSM in England during 2015.
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