ES18.03 The Lung Microbiome and Lung Cancer Progression

Abstract

Cigarette smoke contains multiple carcinogens and has been identified as the major cause of lung cancer. However, the incidence of lung cancer among smokers is 15% and the prevalence of lung cancer among non-smokers is rising. Other environmental factors are likely playing a significant role in cancer pathogenesis. Both inflammation and effector lymphocyte dysfunction have been identified as important in this process. Immune checkpoint molecules, such as programmed death 1 (PD-1), mediates the responses of T cells to neoantigens and are now the target of first line therapy for advanced non-small cell lung cancer (NSCLC).