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Abstract
Increases in blood erythropoietin concentration occur after tissue hypoxemia of anemic, ischemic, or hypoxic origin. In the adult, the site of production is the kidney; in the fetus it is thought to be the liver. 1-5 In the developing sheep there appears to be a gradual liver-to-kidney switch in the site of Ep synthesis; this normally begins about 1 month before term and is completed by 2 months of age. 1 Although at birth one strain of mice born with renal agenesis had normal bioassayable erythropoietin concentrations in the blood and normal erythropoietic activity, z no data regarding erythropoiesis are available on human infants born with severe renal disease manifesting as Potter syndrome (oligohydramnios sequence). The purpose of our study was to determine whether blood and tissue levels of Ep and indicators of erythropoiesis are normal at birth in infants with severe congenital renal disease.
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