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Abstract
Erythropoietin stimulates DNA and heme synthesis by erythroblasts in vitro . Actinomycin-D completely suppresses the ESF stimulation of heme synthesis without affecting heme synthesis in control cultures. At the same concentration, AM depresses DNA synthesis in both ESF and control cultures but does not abolish the stimulation of DNA synthesis by ESF. We conclude that the ESF stimulation of DNA synthesis is not dependent on the stimulation of heme synthesis.
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