Abstract
Incubation of rat marrow cells with hexachloroiridate (4.5–5.5 × 10 −4 M) at 36.5° for 45 hours totally abolishes their DNA synthesis. One hour exposure to erythropoietin considerably stimulates the rate of RNA synthesis of such Iridium treated marrow cells. Since hexachloroiridate is reported to be an agent which inhibits mammalian cell division by blocking cells in the G 1 phase, it seems that early erythropoietin action resulting in stimulated RNA synthesis is independent of DNA synthesis and can take place in cells arrested in G 1 .
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