Abstract
Aim: The efficacy of erythropoietin (EPO) on wound healing has been shown before. There islimited data about the efficacy of EPO on fracture healing. In this study, the efficacy of EPO onclosed forearm fracture healing is searched by an experimental model. Material and method: Twenty eight rats were picked randomly and divided into EPO andControl groups. On the first day, fracture was performed on the right ulna and radius of all rats.500 U/kg daily low dose EPO was administered for each rat in EPO group and the same volumeof isotonic sodium chloride solution was given intraperitoneally in the control group for fivedays. Seven rats from each group were sacrificed at the end of the first week; the others weresacrificed at the end of the third week. Results: At the end of the first week and third week, bone healing scores of EPO group issignificantly higher than the control group according to the histological, clinic and radiologicanalysis. Conclusion: EPO could have positive effects on healing of forearm fracture on rats in acuteand subacute period. Low dose EPO may be a new protective agent against delayed union ornonunion in the risk population to go or not to go to surgical treatment
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
