Abstract
AbstractIn order to test the effect of initial hemolysis on the formation of erythropoietins in vitro, saline suspensions of partially hemolysed and non‐hemolysed washed blood cells were subjected to low atmospheric pressure, and the erythropoietic activity tested by injecting samples of the saline into test rabbits. The recipient animals in the“non‐hemolysed group reacted to the injection with an increase in the erythrocyte and reticulocyte count, while in the ”hemolysed group“ the injection was ineffective save for a transient reticulocytosis. It is concluded that the active agent or its precursor is lost from the blood during initial hemolysis.
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