Abstract
Erythropoiesis during the development of myeloid leukaemia in mice was studied, using assay of radio-iron incorporation in blood, exorepopulation and autorepopulation techniques. These tests indicated a certain tendency of decreasing erythropoiesis during the leukaemic process due to declining numbers of the normal erthropoietic cell precursors.
Highlights
THE mechanism of erythropoiesis has been studied in certain murine diseases; macrocytic anaemia caused by action of mutant alleles at the W locus (Russell and Bernstein, 1966) and haemolytic anaemia, known to be an auto-immune type, in NZB/B1 mice (Helyer and Howie, 1958)
Suspensions of leukaemic spleen cells from mice with advanced leukaemia were injected into groups of mice, 105 cells intravenously
Exorepopulation.-Bone marrow cell grafting: In a group given 106 cells from donors inoculated with leukaemic cells, iron-uptake started to decline from the normal level of 15.5% to 8% on day 7 of the leukaemia (Fig. 3a)
Summary
THE mechanism of erythropoiesis has been studied in certain murine diseases; macrocytic anaemia caused by action of mutant alleles at the W locus (Russell and Bernstein, 1966) and haemolytic anaemia, known to be an auto-immune type, in NZB/B1 mice (Helyer and Howie, 1958). The pathogenesis of erythropoiesis in erythroleukaemia (Friend) was investigated in several laboratories (Mirand ct al., 1961; Ludwig et al, 1964; Brodsky et al, 1966). There has been nio intensive study concerning the erythropoiesis in mnyeloid leukaemia of rodents, except for the Shay chloroleukaemia (acute myeloid type) in rats reported by Handler et al (1968) and Handler and Handler (1970). This paper reports the characteristics of erythropoiesis, i.e. manifestation of anaemia in the late or early stage of the developing myeloid leukaemia in RFM/Un mice, using radio-iron incorporation in blood as an indicator
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