Abstract
Protoporphyrin IX, which had been regarded as ineffective in cell differentiation, induced erythroid differentiation of K562 cell line, and its analogs such as hematoporphyrin IX, mesoporphyrin IX, deuteroporphyrin IX and protoporphyrin IX dimethyl ester were also differentiation inducers. The differentiation induced by these compounds was augmented by a retinoid, as is hemin-induced differentiation.
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