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Abstract
Using low-angle light scattering technique, the features of erythrocyte transformation dynamics (osmotic fragility, the hemolysis level and ratio of different cell forms determined by the spherical index) were revealed in hetero- (golden hamsters Mesocricetus auratus) and homoiothermic (white rats Rattus norvegicus) animals under natural (hibernation) and artificial (suspended animation) hypometabolic states, craniocerebral and immersion hypothermia. In control, golden hamsters exhibited higher levels of erythrocyte osmotic fragility and hemolysis than rats, with transformed erythrocytes (especially stomatocytes) being prevalent. Under artificial hypothermia, regardless of the way of its attaining, depth and duration, the changes were observed that were similar in their directionality but dissimilar in the degree of manifestation: increased osmotic fragility and hemolysis, reduced portion of discocytes (particularly sharp in golden hamsters under suspended animation), increased number of transformed erythrocytes. In contrast, under hibernation the osmotic fragility, hemolysis and number of stomatocytes decreased, the portion of discocytes increased, while the number of prehemolytic forms (spherocytes) also increased. In 24 h, both the osmotic fragility (stronger in hamsters after suspended animation) and the level of hemolysis (particularly after immersion hypothermia) decreased, the portion of discocytes recovered (even exceeding the control level in hamsters after suspended animation and in rats after immersion hypothermia), spherocytes were not detectable in hamsters but elevated in rats. It is likely that the qualitative changes in the erythrocyte population towards its homogeneity detected 24 hours after hypothermia may be mediated not only by the elimination of old and defective cells, erythropoiesis activation and production of high-resistant erythrocytes but also by the fine membrane-stabilizing mechanisms.
Published Version
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