Abstract
Membrane-bound erythrocyte surface sialic acid concentrations in sickle-cell human patients (SS) and in control patients with sickle-cell trait (AS) and normal genes (AA) were assayed. The erythrocyte sialic acid concentration was significantly ( P < 0·001) higher in sickle-cell patients than in non-sicklers and although the concentration was higher in AS than AA individuals the difference was not significant ( P > 0·05). The anaemic state of the SS patients was shown by a significantly ( P < 0·001) lower PCV than in non-sicklers. This finding is discussed in relation to membrane toughness and subsequent membrane loss leading to irreversible sickling of red cells in the deoxygenated state.
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