Abstract
This research aims to simulate a gravity flow fractionation—the process to fractionate erythrocytes through gravitational field using ANSYS simulation software. A particular microfluidic channel was designed as a separation device. The gravitational equilibrium conditions of the erythrocytes and gravitational field as the parameters were chosen, then deriving the erythrocytes’ path through numerical simulations. After the actual analog measurements, there is no big difference between the flow velocity and the pressure under +/–10% atmosphere condition. According to the simulation results, the particle with the size 8 μm (similar to the erythrocyte size) can be separated to the outside channel and discharged from the collecting area, other particles with the size 9 μm will stay in the fluid motion and can be collected in the final collection area for preservation. Through the analog analysis by using the software-ANSYS-Fluent, the complete flowing path of the particles and the feasibility of the Gravity-Flow Fractionation can be directly proven.
Highlights
With the progress of science and technology, all biomedical devices are changed rapidly
According to the simulation results, the particle with the size 8 μm can be separated to the outside channel and discharged from the collecting area, other particles with the size 9 μm will stay in the fluid motion and can be collected in the final collection area for preservation
Environments to investigate the effect on the microfluidic channel, it can be seen clearly that there is no difference between the flow velocity or the pressure inside the internal flow under the normal environment through reference points of inlet end and outlet end of fluid
Summary
With the progress of science and technology, all biomedical devices are changed rapidly. Which combines with semiconductor thin film process, mechanical and electrical integration and other precision technology This technology integrates optoelectronics, machinery, electronics, chemicals, materials with biomedicine to miniaturize products and improves the performance while reducing manufacturing costs. Microchannel is processed on CD and drove the microfluid by centrifugal force to mix the reagent This can be applied to immunoassay [7] [8], cell sorting [9] [10] [11], toxicity analysis [12], protein detection [13] [14], AIDS detection [15] etc. Red blood cells by gravitational field-flow fractionation were studied [16]. It’s anticipated to use the natural gravity to drive blood for erythrocyte cell separation by the correlation study
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