Abstract

Severe sepsis and septic shock are major healthcare problems, affecting millions of people around the world each year, and increasing in incidence [1]. During sepsis there is increased oxidative stress, with reduced body stores of selenium (Se) and lower activity of glutathione peroxidase (GPx1), with patient outcomes of multiple organ failure and death [2]. The objective of this study was to determine the influence of Se concentration in plasma, erythrocytes and erythrocyte GPx1 activity on the length of hospital stay, length of ICU stay and ICU mortality in patients with septic shock.

Highlights

  • Vascular calcification is a regulated process, which associates with coronary artery disease (CAD) and occurs through an increase in transcription factor expression such as RUNX2, MSX2 and alkaline phosphatase (ALP), inducing calcium deposition

  • The objective of this study was to verify the incidence of delirium through the CAM ICU instrument in ICU patients followed by physiotherapists

  • There was a low incidence of delirium in ICU patients followed by physiotherapists

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Summary

Introduction

Vascular calcification is a regulated process, which associates with coronary artery disease (CAD) and occurs through an increase in transcription factor expression such as RUNX2, MSX2 and alkaline phosphatase (ALP), inducing calcium deposition. The objective of this study was to evaluate the tendency of the plasma concentration and clearance of PCT as biomarkers for prognosis of patients with severe sepsis and septic shock, compared with another early prognosis marker, the number of SIRS criteria at sepsis diagnosis. The objective of this study was to evaluate the serum activity of MMP-2 and MMP-9, length of hospital stay, length of ICU stay and mortality in patients with septic shock. The objective of this study was to determine the influence of serum thiamine concentrations on lactate levels, GPx activity, length of hospital stay, length of ICU stay and ICU mortality in patients with septic shock. Hypothermia at ICU admission was associated with greater severity scores and increased hospital mortality in this sample of surgical patients studied.

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