Abstract
The endolymphatic sac (ES) appears to serve as an immunologic/phagocytic defence organ. This may involve both specific and unspecific cell reactions for removal of both endogenous waste products and debris and foreign material. The present study was carried out in order to investigate whether the ES is involved in the removal of blood from the inner ear. The round window was exposed and the stapedial artery experimentally lesioned to cause bleeding. The ES was taken out after various time intervals and analyzed by TEM and LM, care being taken to maintain the structural integrity at all levels. This was done in order to see if the endolymphatic sac is involved in the removal of blood from the inner ear. The results indicate that the ES possesses hitherto unknown specific cellular properties for the disposal of blood and blood corpuscles. It is believed that this system may represent an important physiological function for regulation of homeostatic equilibrium around the inner ear sensory structures. The results also offer further support for the existence of a longitudinal "flow" of endolymph from the cochlea into the ES. Judging from the time it takes for erythrocytes to appear in the duct and sac, this flow would seem to take about 1-2 h in the mouse.
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