Abstract
：Objective To exploreerythrocyte osmotic fragility test and determination of hemoglobin A for screeningneonatal β thalassemia and improve thediagnostic rate of slight β-thalassemia.Methods Cordblood samples were obtained from the full-term newborns in my hospital from January 2009to December 2010. The erythrocyte fragility was detected by erythrocyte osmotic fragilitytest, and hemoglobin A was analyzed quantitatively using the automatic system ofhemoglobin electrophoresis. Results Of 7023 newborns, 6834 were normal and 189 weresuspected to have β thalassemia. 159 wereconfirmed as β thalassemia through geneticanalysis, with a detection rate of 84.13%. A significant difference was found between thenomal newborns and the suspected newborns (P＜0.01). onclusions Cord blooderythrocyte osmotic fragility test and determination of hemoglobin A, in combination withhemoglobin analysis on pateral and maternal family, can be used as an important indicatorfor screening neonatal β thalassemia.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
