Abstract
The rate of osmotic hemolysis and the erythrocyte membrane lipid composition has been studied for blood samples obtained from male donors between 18 and 95 years of age. The rate of hemolysis is found to decrease as a function of age while the membrane cholesterol content increases with age. No significant change in the phospholipid content is detected. A causative relationship between the increase in cholesterol and the decrease in rate is inidicated by in vitro experiments which demonstrate an inverse relationship between the cholesterol content and the rate of hemolysis.
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