Abstract
A total of 710 White and 1070 Black persons living in Porto Alegre, Brazil were tested for the adenylate kinase, adenosine deaminase (ADA), glucose-6-phosphate dehydrogenase (G6PD), phosphogluconate dehydrogenase (PGD) and hemoglobin (Hb) systems. In general the results were those expected in populations of these ethnic groups with some admixture. Two rare phenotypes were found, one involving a “null” ADA allele and another a G6PD non-deficient variant that is being tentatively named Gd(+) “Guaiba”. In the latter system evidence was obtained for the occurrence of somatic selection. Among the Blacks a significant excess of double PGD A / PGD C , Hb A / Hb S heterozygotes were observed. Eight patients with varied forms of immunologic deficiencies showed normal ADA and purine nucleoside phosphorylase levels.
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