Abstract
To the Editor.— I read with interest the article by Kok et al. 1 The authors state that data on erythrocyte (red blood cell) glutathione peroxidase (GSH-Px) (EC 1.11.1.9) activity in patients who have had a myocardial infarction have not been published. We are working on this problem. It is known that GSH-Px is one of the major enzymes involved in the protection of the cell against antiperoxidation, particularly the cells of heart muscle. Selenium-containing GSH-Px acts on hydrogen peroxide and lipids or other organic hydroperoxides. 2 Doroshow et al 3 found that in heart tissue catalase was almost absent and superoxide dismutase had only 27% of the activity found in liver. Only GSH-Px activity is high both in liver and in heart tissues. Batist et al 4 demonstrated that changes in this enzyme in heart cells and in erythrocytes are well correlated. Study.— We determined red blood cell GSH-Px
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