Abstract
A 38-year-old man, user of illicit drugs, cannabis smoker, and alcoholic, presented an evolution of cutaneous, oral, and ophthalmologic lesions a few hours after the use of 5 to 8 tablets of amphetamine and alcohol. In 2011, a similar condition was reported after ingestion of cephalexin. Erythematous macules and papules were observed in the lower and/or upper limbs, dorsum, trunk, and genitalia, with areas of central necrosis (bulls-eye aspects). In the oral examination, multiple shallow ulcers were observed, covered by exudate in multiple sites of the oral mucosa. The diagnosis was erythema multiforme. The patient was treated at the hospital with corticoids, analgesic, and antibiotics. Dental team applied laser therapy (λ660 nm, 100 mW, 1 J, 10 s/point, 0.0028 cm² spot) every day and prescribed mouthwashes (0.05% clobetasol propionate, 2 times/d) until hospital discharge. Drug use may trigger severe manifestations of erythema, with a risk of progression to Stevens-Johnson syndrome. The multiprofessional approach was crucial in this case.
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