Abstract

Erythema induratum of Bazin (EIB) is considered to be a tuberculid reaction and consists of recurrent painful nodules. The differential diagnosis includes diseases like nodular vasculitis, perniosis, polyarteritis nodosa and erythema nodosum. We report the case of a woman with EIB who developed Addison's disease during treatment with anti-tuberculosis drugs with good response to glucocorticoid replacement. The diagnosis was obtained through the clinical picture, positive tuberculin test and positive BCG (bacillus Calmette-Guérin) test on the histological sample. Anti-tuberculosis drugs and glucocorticoid replacement led to disappearance of the signs and symptoms. This is the first description of an association between EIB and Addison's disease. It should be borne in mind that tuberculosis is an important etiological factor for Addison's disease.

Highlights

  • Erythema induratum of Bazin (EIB), known as Bazin disease, tuberculosum, tuberculosis cutis indurativa and nodose tuberculid, is a chronic, nodular eruption that usually occurs on the lower legs of young women

  • It has been correlated with manifestations of tuberculin hypersensitivity consisting of a type of tuberculid that occurs on the legs, whereas nodular vasculitis represents the non-tuberculous counterpart

  • We report the first case of a patient with EIB who developed adrenal insufficiency

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Summary

Introduction

INTRODUCTION Erythema induratum of Bazin (EIB), known as Bazin disease, tuberculosum, tuberculosis cutis indurativa and nodose tuberculid, is a chronic, nodular eruption that usually occurs on the lower legs of young women. No previous case of EIB associated with adrenal insufficiency has been described. We report the first case of a patient with EIB who developed adrenal insufficiency.

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