Abstract
Erythema discromicum perstans is clinically characterized by asymptomatic , hyperpigmented macules of various size on the face, trunk and extremities. It typically occurs in the second decade of life and generally affects those with phototype IV skin. The etiology of erythema discromicum perstans is unknown but associations with endocrinopathies, infestations, infections, and drug allergies have been reported. The association with oral contraceptives and progesterone injections has not been reported yet in the literature. Herein, we report a case of a 34 year old woman who presented with extensive and progressive erythema discromicum perstans induced and/or exacerbated by the ingestion of oral contraceptives and multiple progesterone injections. We aim to emphasize the “probable” side effect of these drugs. Awareness of this probable association deserves attention due to the widespread use of oral contraceptive pills and/or progesterone injections.
Highlights
Erythema discromicum perstans (EDP) first described by Ramirez in 1957 is a rare, benign and chronic disorder included in the group of acquired idiopathic hypermelanoses [1]
We report a case of 34 year old woman who presented with extensive and progressive EDP induced and/or exacerbated by ingestion of oral contraceptives and multiple progesterone injections
Awareness of this probable association deserves attention due to the widespread use of oral contraceptive pills and/or progesterone injections
Summary
Erythema discromicum perstans (EDP) first described by Ramirez in 1957 is a rare, benign and chronic disorder included in the group of acquired idiopathic hypermelanoses [1]. We report a case of 34 year old woman who presented with extensive and progressive EDP induced and/or exacerbated by ingestion of oral contraceptives and multiple progesterone injections. Patient had noticed hyperpigmented lesions over the face after using of oral contraceptive pills due to ovarian cysts. Because of these lesions, the patient discontinued oral contraceptive pills and a progesteron injection was made. Two years ago the patient became pregnant and because of the abortion risk progesteron injections were again made three times at a week’s interval
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