Abstract
Xanthomas are well-circumscribed lesions in the connective tissue of the skin, tendons, or fasciae that predominantly consist of foam cells; these specific cells are formed from macrophages as a result of an excessive uptake of low-density lipoprotein (LDL) particles and their oxidative modification1. The clinical variants of cutaneous xanthomas include eruptive xanthomas, tuberous xanthomas, tendinous xanthomas, plane xanthomas (including xanthelasma), and verruciform xanthomas. Xanthomas can present as early manifestations of systemic disorders and uncommonly as sole manifestations. Early recognition and treatment of the underlying condition decrease morbidity and mortality. Eruptive xanthomas are highly suggestive of hypertriglyceridemia and are often associated with serum triglyceride levels exceeding 1500 to 2000 mg/dL. Occasionally, eruptive xanthomas are the initial sign of diabetes. Eruptive xanthomas have also occurred in association with hypertriglyceridemia-induced pancreatitis2
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