Abstract
Rosenblum, Michael G., Horn, Shirley A., Cheung, Lawrence H., A novel recombinant fusion toxin targeting HER-2/neu–over-expressing cells and containing human tumor necrosis factor. Int. J. Cancer, 88, 267–273 (2000). Due to the authors' error, a mistake appeared in the legend to Figure 6. The figure and correct legend are printed below. The authors regret this error. Western analysis of 2 variants of SKBR-3 cells (insert) demonstrates that SKBR-3-LP cells express approximately 5-fold higher HER2 protein than SKBR-3-HP cells. Direct comparison of the cytotoxic effects of continuous exposure of various concentrations of TNF demonstrates that the cell line expressing higher levels of HER2 was effectively resistant to TNF while the cells expressing low levels of HER2 were sensitive to the cytotoxic effects of TNF.
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