Erratum.

Abstract

Neuropathology and Applied NeurobiologyVolume 49, Issue 3 e12906 ERRATUMFree Access Erratum This article corrects the following: Schwann cells and myelin in human peripheral nerve: Major protein components vary with age, axon size and pathology Alan Pestronk, Robert E. Schmidt, Robert Bucelli, Julia Sim, Volume 49Issue 2Neuropathology and Applied Neurobiology First Published online: March 20, 2023 First published: 18 May 2023 https://doi.org/10.1111/nan.12906AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL In Pestronk et al. [1], Figures 5 and 6 were mislabelled. The correct label letters are below: FIGURE 5. Axonal (Wallerian) degeneration in adult human sural nerve. (Wallerian) degeneration in adult human sural nerve. Loss of neurofilament staining of larger axons is apparent within areas of myelin basic protein (MBP)-stained myelin. (A) Toluidine blue-stained plastic sections show myelin ovoids and irregularly shaped myelin sheaths. Scattered Schwann cells associated with myelin and other endoneurial cells contain lipid debris or droplets. Bar = 10 μM. (B) Neurofilament-stained frozen sections show round pale regions (arrow at the top right of image) that likely represent the loss of larger axons within areas of residual myelin. Smaller axons are relatively preserved. Bar = 20 μM. (C) Ultrastructural analysis shows a damaged axon (left) with irregular cytoplasm inside thick myelin associated with surrounding Schwann cell cytoplasm containing myelin debris and lipid droplets (arrow left). An endoneurial macrophage (right) (not likely a Schwann cell as it has no surrounding basal lamina) contains myelin debris and lipid droplets (arrow right). Bars = 2 μM. (D) Acid phosphatase (AcP) stains scattered endoneurial histiocytes (red). Bar = 50 μM. (E) Neural cell adhesion molecule (NCAM) (green) stains non-myelinating Schwann cells (see I). P0 protein (P0) (red) stains myelin sheaths (see H). There is minimal overlap (yellow). (F) NCAM and MBP show overlap (yellow) on both NCAM cells and some MBP-containing myelin. (G) Many MBP myelin regions have central regions with no neurofilament-stained axons (arrow). (H) Scattered P0 regions have central regions with no neurofilament-stained axons (arrow). (I) Most NCAM (red) regions have associated co-stained axons (yellow) suggesting acute axon loss is less prominent among small-sized axons. Bars for E–I = 100 μM. FIGURE 6. Demyelination (Acquired & CMT1A) in adult human sural nerve. (acquired and CMT1A) in adult human sural nerve. A–F = Acquired Demyelination: CIDP nerves with reduced neural cell adhesion molecule (NCAM)-stained Schwann cells or abnormal myelin composition. (A) Toluidine blue-stained plastic sections show a few axons with thin myelin sheaths and some intermediate-sized axons with no myelin (arrow). Bar = 10 μM. (B) Neurofilament-stained frozen sections show scattered larger axons among clusters of smaller axons. Bar = 50 μM. (C) Scattered larger, neurofilament-stained axons (arrow) have no associated P0 protein (P0)-stained myelin. P0 staining around other axons is present but pale. (D) NCAM-stained cells are reduced in number. Scattered NCAM cells have no associated axon. Large and small axons are reduced in number. (E) Some larger neurofilament-stained axons have no myelin basic protein (MBP)-stained myelin sheath but may have mild MBP co-staining (yellow). (F) MBP-stained myelin sheaths are abnormal with only patchy, or reduced P0 co-stain (arrow), a pattern not seen in normal nerves. G–L = CMT1A: Nerve with large onion bulbs. (G) Toluidine blue-stained plastic sections show a few axons with thin myelin sheaths. Onion bulbs (arrow) are present with or without myelinated axons. Bar = 10 μM. (H) Neurofilament-stained frozen sections with Gömöri co-stain show onion bulbs with or without central axons. Some onion bulbs have small axons in and around their layers. Bar = 20 μM. (I) P0 is present in cells in onion bulb layers. (J) NCAM is abundant in cells in onion bulb layers. (K) MBP is present around some larger axons and co-stains other large axons without apparent surrounding stain. (L) NCAM and P0 co-stain (yellow) cells in onion bulb layers in a manner similar to staining of Büngner band cells in nerves with axon loss (Figure 3E). Bars for all fluorescent stains = 100 μM. The publisher sincerely apologises for these inaccuracies and any inconvenience this may have caused. REFERENCE 1Pestronk A, Schmidt RE, Bucelli R, Sim J. Schwann cells and myelin in human peripheral nerve: major protein components vary with age, axon size and pathology. Neuropathol Appl Neurobiol. 2023; 49(2):e12898. doi:10.1111/nan.12898 Volume49, Issue3June 2023e12906 ReferencesRelatedInformation