Abstract
Alcoholism: Clinical and Experimental ResearchVolume 31, Issue 9 p. 1611-1611 Free Access Erratum This article corrects the following: ABSTRACTS—POSTERS Volume 31Issue s2Alcoholism: Clinical and Experimental Research pages: 9A-248A First Published online: May 16, 2007 First published: 12 October 2009 https://doi.org/10.1111/j.1530-0277.2007.00504.xAboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract 482 in the 2007 RSA Supplement had several authors missing from the printed abstract. The corrected abstract appears below: 482 GENETIC ASSOCIATION OF THE CHOLINERGIC NICOTINIC RECEPTOR A5A3B4 GENE CLUSTER WITH TOBACOCO AND ALCOHOL USE IN YOUNG ADULTS Isabel R. Schlaepfer, Alan C. Collins, Robin P. Corley, Thomas J. Crowley, John K. Hewitt, Nicole Hoft, Christian J. Hopfer, Kenneth Krauter, Jeffrey Lessem, Soo Hyun Rhee, Andrew Smolen, Michael C. Stallings, Susan E. Young, and Marissa A. Ehringer 1480 30th St., Boulder, CO The genetic factors that contribute to alcohol and tobacco problem use still remain to be elucidated. Epidemiological studies have revealed that the comorbid use of these substances is likely due in part to shared genes involved in the molecular responses to both nicotine and alcohol. Our study examines the genetic association between nine variations (SNPs) in the genomic region containing the CHRNA5 A3 and B4 gene cluster (A5A3B4) and several phenotypes of alcohol and tobacco use in an ethnically diverse youth sample. SNP frequency calculations revealed ethnic-specific allele distributions in Caucasians, African-Americans and Hispanics. Therefore, analyses were conducted in the full sample, including ethnicities as covariates, and in each of the three ethnic sub-samples using the statistical genetics program WHAP. Five SNPs were found to be associated with age of initiation of tobacco use, representing all three genes (0.0003 <p <0.01). Four SNPs were found to be associated with age of initiation of alcohol use (three of which are overlapping with the tobacco-associated SNPs; 0.007 <p <0.02). In summary, these exploratory results indicate that the A5A3B4 genes are plausible candidates for influencing smoking and drinking behaviors. Additional research on these variants is underway in our lab to establish replication and functionality. Reference 30th Annual Meeting of the Research Society on Alcoholism, July 7–11, 2007—Chicago, Illinois. Alcohol Clin Exp Res 31(s2):129A, doi: DOI: 10.1111/j.1530-0277.2007.00412.x. Wiley Online LibraryGoogle Scholar Volume31, Issue9September 2007Pages 1611-1611 ReferencesRelatedInformation
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