Abstract
Bleomycin (BLM) is an antitumor antibiotic produced by a strain of Streptomyces verticillus (1). Clinically employed bleomycin (Blenoxane) is a mixture of 11 active components. Of these, bleomycin A2 (BLM A2) , 1(2), is the most abundant, accounting for 55-70% (w/w) of the mixture. Bleomycin is of value in the treatment of squamous cell carcinomas, lymphomas, and testicular carcinomas (3,4). The mechanism of action of bleomycin is not understood. Most of the early efforts as well as those in progress have focused on the interaction of bleomycin, most often bleomycin A2 , with DNA. The glycolpeptide is capable of 11 active components. Of these, bleomycin A2 (BLM A2 ) , 1(2), is the most abundant, accounting for 55-70% (w/w) of the mixture. Bleomycin is of value in the treatment of squamous cell carcinomas, lymphomas, and testicular carcimixture prevents DNA breakage. It is known that these metal ions complex to bleomycin and in so doing apparently inactivate the drug.
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