Erratum to “a single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition”

Abstract

On page 340, the following sentence should be added to the last paragraph:MN9D cells were established by Alfred Heller of University of Chicago (Choi, H.K., Won, L.A., Kontur, P.J., Hammond, D.N., Fox, A.P., Wainer, B.H., Hoffmann, P.C., and Heller, A. (1991). Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cells fusion. Brain Res. 552: 67–76). On page 340, the following sentence should be added to the last paragraph: MN9D cells were established by Alfred Heller of University of Chicago (Choi, H.K., Won, L.A., Kontur, P.J., Hammond, D.N., Fox, A.P., Wainer, B.H., Hoffmann, P.C., and Heller, A. (1991). Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cells fusion. Brain Res. 552: 67–76). A Single-Subunit NADH-Quinone Oxidoreductase Renders Resistance to Mammalian Nerve Cells against Complex I InhibitionSeo et al.Molecular TherapySeptember, 2002In BriefNumerous studies suggest that dysfunction of mitochondrial proton-translocating NADH-ubiquinone oxidoreductase (complex I) is associated with neurodegenerative disorders, such as Parkinson's disease and Huntington's disease. Development of methods to correct complex I defects seems important. We have previously shown that the single-subunit NADH dehydrogenase of Saccharomyces cerevisiae (Ndi1P) can work as a replacement for complex I in mammalian cells. Using a recombinant adeno-associated virus vector carrying the NDI1 gene, we now demonstrated that the Ndi1 enzyme was successfully expressed in the dopaminergic cell lines rat PC12 and mouse MN9D. Full-Text PDF Open Archive