Abstract
Purpose: To investigate the antioxidant and anti-inflammatory effects of aqueous leaf extract of T. laurifolia against alcoholic liver injury in rats.
 Methods: Male Wistar rats were administered either normal saline, ethanol (EtOH), normal saline with low or high dose T. laurifolia leaf extract (TL-LD or TL-HD), EtOH with TL-LD or EtOH with TL-HD. Blood biochemical indices: hepatic malondialdehyde (MDA) levels, liver histopathology, hepatic cytochrome P450 2E1 (CYP2E1), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and proinflammatory cytokines, including interleukin 1 beta (IL-1β) and tumor necrotic factor alpha (TNF-α) mRNA expressions, were determined using standard methods.
 Results: The leaf extract of T. Laurifolia decreased hepatic MDA levels, improved liver pathology and down-regulated mRNA expressions of CYP2E1, NADPH oxidase and pro-inflammatory cytokinesin ethanol-treated rats.
 Conclusion: These results demonstrate that aqueous extract of T. Laurifolia exerts hepatoprotective effect against alcoholic liver injury through a mechanism involving inhibition of oxidative stress and inflammation.
Highlights
Erratum for “Effect of aqueous leaf extract of Thunbergia laurifolia on alcohol-induced liver injury in rats”
Tropical Journal of Pharmaceutical Research is indexed by Science Citation Index (SciSearch), Scopus, International Pharmaceutical Abstract, Chemical Abstracts, Embase, Index Copernicus, EBSCO, African Index Medicus, JournalSeek, Journal Citation Reports/Science Edition, Directory of Open Access Journals (DOAJ), African Journal Online, Bioline International, Open-J-Gate and Pharmacy Abstracts
Summary
Erratum for “Effect of aqueous leaf extract of Thunbergia laurifolia on alcohol-induced liver injury in rats” Sarawoot Palipoch1*, Phanit Koomhin1, Chuchard Punsawad1, Prasit Suwannalert2
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