Erratum: “A Novel Method for the Development of Environmental Public Health Indicators and Benchmark Dose Estimation Using a Health-Based Endpoint for Chlorpyrifos”

Abstract

Vol. 126, No. 9 ErratumOpen AccessErratum: “A Novel Method for the Development of Environmental Public Health Indicators and Benchmark Dose Estimation Using a Health-Based Endpoint for Chlorpyrifos”is correction ofA Novel Method for the Development of Environmental Public Health Indicators and Benchmark Dose Estimation Using a Health-Based End Point for Chlorpyrifos Todd J. Zurlinden and Brad Reisfeld Todd J. Zurlinden Search for more papers by this author and Brad Reisfeld Search for more papers by this author Published:6 September 2018CID: 099001https://doi.org/10.1289/EHP4279AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit The estimated exposure thresholds for RBC acetylcholinesterase (AChE) inhibition and plasma butyrylcholinesterase (BuChE) inhibition were listed incorrectly in the Results as “99% available RBC AChE, and 90% available plasma BuChE.” The correct values are 99.98% for available RBC AChE and 96.25% for available plasma BuChE.In addition, the RBC AChE level associated with a 15% cognitive deficit, based on data from Farahat et al. (2003), was derived incorrectly as BM sub RBC – AchE equals open parenthesis 100 minus 80 close parenthesis divided by 100 equals 0.20BMRBC–AChE=(100−80)/100=0.20. The correct value is BM sub RBC – AchE equals open parenthesis 100 minus 80 close parenthesis divided by 80 equals 0.25BMRBC–AChE=(100−80)/80=0.25. The estimate shown in the original Figure 5 for the level of BM sub AChEBMAChE associated with a 15% cognitive deficit in Farahat et al. (2003) also was incorrect. The corrected figure is included in this erratum.Figure 5. Predictions of human-specific cognitive deficits from measurable biomarkers of exposure. BM sub CPF, BM sub AChEBMCPF,BMAChE, and BM sub BuChEBMBuChE, are the independent biomarker of exposure variables for Equation 2 and correspond to peak plasma chlorpyrifos (CPF) concentration, minimum blood acetylcholinesterase (AChE) inhibition and minimum blood butyrylcholinesterase (BuChE) inhibition, respectively. Dashed lines represent 95% prediction intervals, and the solid circle (•) represents measured fractional cognitive deficit data from Farahat et al. (2003) using the differences in performance of the Benton Visual Retention Test between the exposed and unexposed groups and fractional plasma AChE activity from the reported plasma AChE activity.The authors confirm that these changes do not affect the study conclusions.The authors regret these errors.ReferenceFarahat TM, Abdelrasoul GM, Amr MM, Shebl MM, Farahat FM, Anger WK. 2003. Neurobehavioural effects among workers occupationally exposed to organophosphorous pesticides. Occup Environ Med 60(4):279–286, PMID: 12660376, 10.1136/oem.60.4.279. Crossref, Medline, Google ScholarFiguresReferencesRelatedDetailsRelated articlesA Novel Method for the Development of Environmental Public Health Indicators and Benchmark Dose Estimation Using a Health-Based End Point for Chlorpyrifos20 April 2018Environmental Health Perspectives Vol. 126, No. 9 September 2018Metrics About Article Metrics Publication History Manuscript received1 August 2018Manuscript accepted1 August 2018Originally published6 September 2018 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.