Abstract
This investigation covers studies on the concentrations of Polycyclic Aromatic Hydrocarbons (PAHs) in Golden Horn and their effects on Ethoxyresorufin O-deethylase EROD activities of human hepatocellular carcinoma cell line, HepG2. Water samples were collected from eight different stations around Golden Horn. Concentrations of total water PAHs ranged from 3.8 ng/L to about 259.7 ng/L. CYP1As enzymes were determined based on EROD Activity. A good correlation between total PAHs and EROD activity was observed. The analytical detection and biochemical EROD activity showed that the aquatic ecosystem around Golden Horn contained some hazardous PAHs. Possible sources for these chemicals could be industrial discharge and domestic wastewaters, transportation and shipping activities. Furthermore this study showed that EROD activity could be used as a bio-monitoring tool for the health effects of PAHs in aquatic ecosystems. Key words: EROD, CYP1As, HepG2, Golden Horn, PAHs.
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