Abstract
p21(WAF1/CIP1) and p27(Kip1) cyclin dependent kinase inhibitor (CDKI) genes are considered the markers of DNS damage and cell senescence [1 – 5]. Very few existing publications do not analyse the impact of stresses associated with organ, procurement (harvesting, preservation and engraftment) and various post Tx complications (acute cellular rejection, nephrotoxicity etc.) on the profile of gene expression. The aim of the current study is to evaluate the influence of ischemial reperfusion (I/R) on the expression of p21(WAF1/CIP1) and p27(Kip1) CDKI genes, using an experimental model of ex-vivo hemoperfusion of primate kidneys. To our knowledge, this is the first report on increased expression of these genes in all structures of xenoperfused kidneys.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
