Abstract
This 3‑part article aims to treatment possibilities to review maintain mobility and quality of life in patients with heart failure, covering the aspects of guideline-conform drug therapy, treatment of comorbidities, and the influence of exercise training. This second part discusses that intravenous administration of ferric carboxymaltose in patients with iron deficiency can improve exercise capacity. Small studies have indicated that testosterone administration can be useful in highly selected patients with low muscle mass. Initial positive data are available for sodium-glucose Co-transporter 2 (SGLT2) inhibitors in patients with HFrEF and HFpEF. Interventional pulmonary vein isolation used to restore sinus rhythm in patients with atrial fibrillation and heart failure can have positive effects on exercise capacity. Treatment of other comorbidities of heart failure, such as sleep-disordered breathing, diabetes mellitus, chronic kidney disease, or depression, showed some improvements in exercise capacity and/or quality of life but the meaningfulness of the available data is limited.
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