Abstract
Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3–10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide.
Highlights
IntroductionThe target genes of an estrogen receptor are in control of cancer cell development in estrogen-dependent breast tumors
Estrogen is responsible for breast cancer growth
The target genes of an estrogen receptor are in control of cancer cell development in estrogen-dependent breast tumors
Summary
The target genes of an estrogen receptor are in control of cancer cell development in estrogen-dependent breast tumors. P. eryngii contains amino acids, vitamins, and dietary fiber [10] It includes polysaccharides [11,12], pleurone [7], ergostane-type sterols [13], and eryngiolide A [14]. These chemical constituents exhibit biological activities such as the antioxidant [11] and antitumor activities [12] of a polysaccharide, HNE-inhibitory effects of pleurone [7], and cytotoxicity against human cancer cell lines of eryngiolide A [14]. Sci. 2017, 18, 2479 structure [15], and a 9,11-seco-ergostane and five ergostane-type sterols [16] from the fruiting sbtouddiye,swofe Pis.oelraytnedgii1.0Ienrgaocsotanntein-tuyipneg sstteurodlys,, wanediseolulactieddat1e0d ethrgeossttrauncetu-tryepseofsttewroolsn,eawndcoemlupcoiduantdesd; (t2h2eEs)t-r5uαc,t6uαr-eespoofxtywerognosetwa-8c,o1m4,p22o-utrnidens;e-(32β2E,7)β-5-dαi,o6lα(-1e)p,oaxnyder5gαo,s6tαa--e8p,1o4x,2y2e-rtgrioesnt-e8-(31β4,)7-βen-de-i3oβl ,(71α),-daniodl (52α).,6Iαn-aedpdoxityioenrg, othste-8is(o14la)t-eednec-o3nβs,7tiαtu-deniotls(w2)e.rIeneavdadluitaiotend, tfhoer iinsohliabtietodrcyoancsttiivtuiteienstsown earreomevaatlausaet.ed for inhibitory activities on aromatase
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