Abstract

The treatment of methyl lysergate with mercuric acetate in methanol yields, instead of the expected 10 - methoxy - 6 - methyl - ergoline - 8 β - carboxylic acid methyl ester ( 2), 10 - methoxy - 8,9 - didehydro - 6 - methyl - ergoline - 8 - carboxylic acid methyl ester ( 3), whose structure is demonstrated. From 3, penniclavine ( 14) and isosetoclavine ( 15) were prepared according to Scheme 1.

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