Abstract
The ergogenic properties of a 7-Chinese traditional medicine water extract (Ligustrum lucidum ait, LLA), which is composed of the essences of Lycii fructus, Crataegi fructus, Phyllanthi fructus, Chrysanthemi flos, Coicis semen, Ganoderma lucidum, and Zizyphi fructus, were studied using aged mice. Mice were chronically (one month) administered LLA (0.1% and 1%) in the drinking water. Mice pre-treated with LLA showed a good appetite; however, they exhibited a lower rate of body weight increase compared to control mice. In mice subjected to the rotarod test, 1% LLA treatment provided effective adaption to fatigue and significantly increased the duration of mice on the rotarod. In locomotor activity test, 1% LLA potentiated mice mobility and significantly increased rearing behavior. In the antioxidant experiment, 1% LLA treatment significantly increased superoxide dismutase activity in the spleen and liver glutathione levels. These findings suggest that LLA may be utilized as an antifatigue agent, which may function through its antioxidant activity.
Highlights
A 7-Chinese traditional medicine water extract (Ligustrum lucidum ait, LLA) has been used for more than thirty years in China and Japan, and is composed of the essences of Lycii fructus from Lycium chinense Miller, Crataegi fructus from Crataegus cuneata Siebold et Zuccarini, Phyllanthi fructus from Phyllanthus emblica L., Chrysanthemi flos from Chrysanthemum morifolium, Zizyphi fructus from Zizyphus jujuba Miller var. inermis Rehd, Ganoderma lucidum, and Coicis semen from Coix lacryma-jobi L. var. mayuen Stapf
The ergogenic properties of a 7-Chinese traditional medicine water extract (Ligustrum lucidum ait, LLA), which is composed of the essences of Lycii fructus, Crataegi fructus, Phyllanthi fructus, Chrysanthemi flos, Coicis semen, Ganoderma lucidum, and Zizyphi fructus, were studied using aged mice
1% LLA treatment significantly increased superoxide dismutase activity in the spleen and liver glutathione levels. These findings suggest that LLA may be utilized as an antifatigue agent, which may function through its antioxidant activity
Summary
A 7-Chinese traditional medicine water extract (Ligustrum lucidum ait, LLA) has been used for more than thirty years in China and Japan, and is composed of the essences of Lycii fructus from Lycium chinense Miller, Crataegi fructus from Crataegus cuneata Siebold et Zuccarini, Phyllanthi fructus from Phyllanthus emblica L., Chrysanthemi flos from Chrysanthemum morifolium, Zizyphi fructus from Zizyphus jujuba Miller var. inermis Rehd, Ganoderma lucidum, and Coicis semen from Coix lacryma-jobi L. var. mayuen Stapf. It has been reported that polysaccharides from Lycium chinense, a component of LLA, improved superoxide dismutase (SOD) activity in damaged rat testes, and its antioxidant activities were comparable to the normal antioxidant, vitamin C [2,3]. It was found that Emblica, another component of LLA, had a higher content of vitamin C, accounting for 45% - 70% of the antioxidant activity [6]. Dicaffeoylquinic acids from Chrysanthemi Flos and six phenolic compounds from Coicis Semen showed potent DPPH radical scavenging activity [7,8]. These may contribute greatly to the antioxidant property of LLA
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
