Abstract
Erdheim-Chester disease (ECD) is an uncommon, sporadic, non-Langerhans cell histiocytosis characterized by xanthomatous or xanthogranulomatous histiocyte infiltration of affecting both bone and soft tissue systems. Herein we report the imaging features of four cases of ECD who had different multiorgan manifestations. The nuclear medicine imaging modalities consisting of technetium-99m methylene-diphosphonate (Tc-99m MDP) scintigraphy, Fluorine-18 2-deoxy-2-fluoro-D-glucose positron emission tomography/computed tomography (F-18 FDG PET/CT) and Ga-68 DOTA-octreotate (DOTA-TATE) PET/CT are useful methods to determine the ordinarily and extraordinarily heterogeneous clinical manifestations of ECD.
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