Abstract
BackgroundThe relationship between ERCC2 polymorphisms and the risk of radiotoxicity remains inconclusive. The aim of our study is to systematically evaluate the association between ERCC2 polymorphisms and the risk of radiotoxicity.MethodsPublications were identified through a search of the PubMed and Web of Science databases up to August 15, 2015. The pooled odds ratios (ORs) with corresponding 95 % confidence intervals (CIs) were calculated to evaluate the association between ERCC2 polymorphisms and radiotoxicity. Trial sequential analysis (TSA) and power calculation were performed to evaluate the type 1 and type 2 errors.ResultsEleven studies involving 2584 patients were ultimately included in this meta-analysis. Conventional meta-analysis identified a significant association between ERCC2 rs13181 polymorphism and radiotoxicity (OR = 0.71, 95 % CI: 0.55-0.93, P = 0.01), but this association failed to get the confirmation of TSA.ConclusionsThe minor allele of rs13181 polymorphism may confer a protect effect against radiotoxicity. To confirm this correlation at the level of OR = 0.71, an overall information size of approximate 2800 patients were needed.Electronic supplementary materialThe online version of this article (doi:10.1186/s13014-015-0558-6) contains supplementary material, which is available to authorized users.
Highlights
Radiotherapy is commonly used in cancer treatment
‘Radiogenomics’ is the study of genetic variation associated with response to radiotherapy, with a main purpose of establishing single nucleotide polymorphism (SNP) based risk models that can stratify patients according to radio-sensitivity [6, 7]
Our data revealed that the major allele of rs13181 presents as a risk allele, which means the minor allele confers a protect effect against the appearance of radiotoxicity
Summary
At least half of cancer patients will require radiotherapy with either curative or palliative intent [1]. The standard radiotherapy schedule was recommended treating the cancer patients as a whole, which was miscellaneous with patients of different radio-sensitivity. The radio-resistive patients who can bear more doses of radiotherapy were confined in the ‘Radiogenomics’ is the study of genetic variation associated with response to radiotherapy, with a main purpose of establishing single nucleotide polymorphism (SNP) based risk models that can stratify patients according to radio-sensitivity [6, 7]. Candidate gene association studies have identified several potential predictors for radio-sensitivity. The relationship between ERCC2 polymorphisms and the risk of radiotoxicity remains inconclusive. The aim of our study is to systematically evaluate the association between ERCC2 polymorphisms and the risk of radiotoxicity
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