Eradication treatment of Pseudomonas Aeruginosa in pediatric patients with Cystic Fibrosis.

Abstract

<b>Objectives:</b> Pseudomonas aeruginosa (PA) eradication success rate varies greatly in cystic fibrosis (CF). PA eradication rate of our center via IV antibiotics was 21.6% previously. Therefore, our center’s eradication protocol was evaluated and changed. Our primary aim was to determine the efficacy of the new eradication regimen. Our secondary aim was to evaluate the changes in BMI and FEV1 values during the follow-up period after PA detection. <b>Methods:</b> Patients with CF in whom PA was detected for the first time or not grown during the previous year in respiratory tract samples were included in the study. Eradication is defined as no growth of PA during the 12 months following the usage of eratication treatment. The treatment applied in patients with Pseudomonas aeruginosa growth is shown in the Table1. <b>Results:</b> 28 CF patients were included in the study. The median age of patients at first PA isolation was 5,5 years (25th-75th p was 2,5-12,75 years) and at diagnosis of CF was 2,25 months (25th-75th p was 1-4month).17,9% (n=5) of the patients had new-onset symptoms. Of 9 patients whose PA type was determined, 5 were non-mucoid PA. Oral ciprofloxacin and inhaled toramycin were used in 53,6% of the patients (n=15), oral ciprofloxacin, tobramycin/ colistin nebule in 14,3% (n=4). IV antibiotics were used in 32,2% (n=9) of the patients. Eradication was successful in 75% (n=21) of patients. There was no significant difference in baseline and 12th month BMI and FEV1 values of patients. <b>Conclusions:</b> This study demonstrated that new eradication protocol was applied succeccully and eradication rate was found to be higher than the previous protocol.