Eradication Rate Using a First-line Triple Therapy for Helicobacter pylori Infection in Yeongdong, Gangwon Province, Korea

Abstract

Background/Aims: The eradication success rate of <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection with a first-line standard triple therapy (STT) has been decreasing in Korea. However, treatment outcomes of <i>H. pylori</i> infection in Yeongdong, Gangwon Province have been scarcely reported. This study aimed to investigate the treatment outcomes of <i>H. pylori</i> infection in a single tertiary care hospital with regional characteristics.Materials and Methods: From July 2018 to June 2019, a total of 592 patients who underwent STT consisting of a proton pump inhibitor, amoxicillin, and clarithromycin for 7 to 14 days as a first-line <i>H. pylori</i> eradication therapy were included. Demographic data and treatment outcomes were retrospectively reviewed using medical records.Results: The median age of 592 patients was 58 years (range 23 to 86) and 329 patients (55.6%) were men. The indication for eradication therapy included chronic atrophic gastritis (57.9%), peptic ulcer disease (19.6%), and gastric neoplasm after endoscopic resection (5.9%). Most patients (92.2%) received a 7-day course of STT. Eradication rate of STT was 64.0% (379/592). Rescue therapy was performed in 146 patients, and the final eradication rate reached 85.6% (507/592).Conclusions: Eradication rate of STT in Yeongdong area of Gangwon Province was unsatisfactory, warranting the consideration of a first-line eradication regimen other than STT.