ERADication of ion channels destined for the plasma membrane. Focus on “Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of β-cell ATP-sensitive potassium channels”

Abstract

surface expression of ion channels and receptors on the plasma membrane is of critical importance in the control of cellular signaling and communication. Each cell contains a menagerie of plasma membrane proteins, many of them oligomeric ion channels, receptors, and cell adhesion molecules. Proper