Abstract
<p indent=0mm>Membrane contact sites (MCS) between endoplasmic reticulum (ER) and plasma membrane (PM), named ER-PM junctions, are crucial for lipid transfer and calcium signaling. ER-PM junction occupies 12% of PM in neurons and is essential for excitation-contraction coupling (ECC) in muscle cells. Currently, the dynamics and biological function of ER-PM junctions in neurons still remain elusive, and known information of proteomics within this region is also limited. The regulation and physiological/pathological function of calcium release-activated calcium (CRAC) channels, well established tethers that mediate ER-PM contacts, are waiting to be further unraveled. Recent advances in super-resolution imaging, optogenetic technology and proximity labeling provide possible solutions to address the aforementioned scientific questions. This review summarized recent advances in understanding the dynamics and proteomics of ER-PM junctions as well as CRAC signaling in muscle cells, and further directions of related research was briefly discussed.
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