Abstract
What defines whether an endosome follows the degradative pathway or fuses with the plasma membrane to release exosomes? In this issue ofJCB, Fredrik Verweij and colleagues(2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112032)demonstratehow secretory endosomes are guided by ER-endosome contacts to take a cellular detour and several identity transitions for efficient exosome release.
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