Equol, a Clinically Important Metabolite, Inhibits the Development and Pathogenicity of Magnaporthe oryzae, the Causal Agent of Rice Blast Disease.

Jiaoyu Wang,Ling Li,Guochang Sun,Rongyao Chai,Yanli Wang,Yeshi Yin,Zhuokan Gu

doi:10.3390/molecules22101799

Abstract

Equol, a metabolite of soybean isoflavone daidzein, has been proven to have various bioactivities related to human health, but little is known on its antifungal activity to plant fungal pathogens. Magnaporthe oryzae is a phytopathogenic fungus that causes rice blast, a devastating disease on rice. Here, we demonstrated that equol influences the development and pathogenicity of M. oryzae. Equol showed a significant inhibition to the mycelial growth, conidial generation and germination, and appressorial formation of M. oryzae. As a result, equol greatly reduced the virulence of M. oryzae on rice and barley leaves. The antifungal activity of equol was also found in several other plant fungal pathogens. These findings expand our knowledge on the bioactivities of equol.

Highlights

Equol (4,7-isoflavandiol) was discovered by Marrian et al in 1932 when they separated hydroxyestrone from pregnant mare urine, and determined its molecular formula as C15H1403
The effectInhibits of equol on the mycelia of M. oryzae was tested on complete medium (CM)
We firstly we firstly demonstrated that equol, a metabolite from natural soy isoflavone, has antifungal activities we firstly demonstrated that equol, a metabolite from natural soy isoflavone, has antifungal activities demonstrated that equol, a metabolite from natural soy isoflavone, has antifungal activities against againstrice riceblast blastpathogen pathogenM

Summary

Introduction

Equol (4,7-isoflavandiol) was discovered by Marrian et al in 1932 when they separated hydroxyestrone from pregnant mare urine, and determined its molecular formula as C15H1403. Despite its safety and adverse effects still being held under suspicion by the medical and scientific community, (S)-equol and its related compounds have been used in many dietary supplements for their potential protective effects against aging, skin conditions, hair loss, prostate cancer, obesity, hot flashes, menopause, osteoporosis, heart disease, and neurologic conditions [9,10]. These studies rarely concerned the Molecules 2017, 22, 1799; doi:10.3390/molecules22101799 www.mdpi.com/journal/molecules

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