Abstract
To measure binding affinity of copper, one of the heavy metals in particulate matter (PM) was applied to soft contact lenses made of two different materials because contact lenses are readily exposed to PM. Copper binding to ionized silicon hydrogel lens yielded an equilibrium association constant K a,eq value of 14.03 μM without color change of lens, compared to that of 19.16 μM for copper binding to de-ionized hydrogel lenses with color change of lens. The results indicated that the color change of lens is not consistent with the concentration of cooper deposition on lens, and copper bound relatively stronger in ionized silicon hydrogel lens than in de-ionized hydrogel lens. Therefore, the continuous exposure of contact lenses to high PM levels might lead to heavy metal deposition on the lens, which would be detrimental to ocular health.
Highlights
Particular matter (PM), known as particle pollution, is a complex mixture of extremely small particles including acids, organic chemicals, metals and dust, and liquid droplets [1]
Even though contact lenses are commonly used to correct vision, little is known about the direct influence of copper or metals in PM on contact lenses
We firstly reported a simple method of measuring the binding of copper to lenses and characterized the binding affinity of copper on lenses
Summary
Particular matter (PM), known as particle pollution, is a complex mixture of extremely small particles including acids, organic chemicals, metals and dust, and liquid droplets [1]. Keywords Binding affinity Á Copper Á Equilibrium association constant Á Hydrogel lens Á Particulate matter The color changes of contact lenses were observed, and absorbance of copper solution was monitored. Equilibrium analysis of copper binding to lenses
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